Status:
NOT_YET_RECRUITING
A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke
Lead Sponsor:
Beijing Tiantan Hospital
Conditions:
Cerebral Small Vessel Diseases
Ischemic Stroke
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to construct a registry platform for microcirculatory disorders in a large sample of Chinese patients with cerebral small vessel disease and ischemic stroke; To explore the role of mic...
Detailed Description
Cerebral small vessel disease (CSVD) is a clinical syndrome with imaging and pathological changes, which is caused by various structural abnormality or functional dysfunction of small blood vessels in...
Eligibility Criteria
Inclusion
- Study 1:
- Age ≥ 18 years old.
- Acute ischemic stroke within 7 days of onset.
- Sign an informed consent form.
- Study 2:
- Age ≥ 18 years old.
- Ischemic stroke during recovery period, within 30 days to 1 year of onset.
- Sign an informed consent form.
- Study 3:
- Age ≥ 18 years old.
- Within 3 years, there are characteristic lesions of cerebral small vessel disease on head MRI or CT, and they meet at least one of the following criteria:
- Paraventricular or deep white matter hyperintensities, Fazekas total score ≥ 2;
- Paraventricular or deep white matter hyperintensities, Fazekas total score=1, and at least two vascular risk factors (hypertension, hyperlipidemia, diabetes, current smoking, obesity, history of coronary heart disease, history of stroke).
- Paraventricular or deep white matter hyperintensities, Fazekas total score=1, with ≥ 1 lacune.
- New recent subcortical small infarcts.
- Sign an informed consent form.
Exclusion
- Study 1:
- Cerebral hemorrhage and subarachnoid hemorrhage within 3 months of onset.
- There are untreated cerebral vascular malformations or untreated aneurysms (diameter\>3mm).
- Confirmed neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Parkinson's syndrome, etc.
- A mental illness diagnosed according to the DSM-V diagnostic criteria.
- There are clear diagnoses of non-vascular white matter lesions, such as multiple sclerosis, adult white matter dysplasia, metabolic encephalopathy, etc.
- Unable to cooperate in completing follow-up visits due to geographical or other reasons.
- The patient also participated in other clinical trials.
- Study 2:
- Cerebral hemorrhage and subarachnoid hemorrhage within 3 months of onset.
- There are untreated cerebral vascular malformations or untreated aneurysms (diameter\>3mm).
- Confirmed neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Parkinson's syndrome, etc.
- A mental illness diagnosed according to the DSM-V diagnostic criteria.
- There are clear diagnoses of non-vascular white matter lesions, such as multiple sclerosis, adult white matter dysplasia, metabolic encephalopathy, etc.
- Unable to cooperate in completing follow-up visits due to geographical or other reasons.
- The patient also participated in other clinical trials.
- Study 3:
- Cerebral hemorrhage and subarachnoid hemorrhage within 3 months of onset.
- There are untreated cerebral vascular malformations or untreated aneurysms (diameter\>3mm).
- Confirmed neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Parkinson's syndrome, etc.
- A mental illness diagnosed according to the DSM-V diagnostic criteria.
- There are clear diagnoses of non-vascular white matter lesions, such as multiple sclerosis, adult white matter dysplasia, metabolic encephalopathy, etc.
- Unable to cooperate in completing follow-up visits due to geographical or other reasons.
- The patient also participated in other clinical trials.
Key Trial Info
Start Date :
October 30 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
20000 Patients enrolled
Trial Details
Trial ID
NCT06077305
Start Date
October 30 2023
End Date
December 31 2026
Last Update
October 19 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Beijing Tiantan Hospital
Beijing, China, 100050