Status:
UNKNOWN
Muscle Stem Cell Quality in Atrophy
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Muscle Weakness
Atrophy, Muscle
Eligibility:
All Genders
50-80 years
Brief Summary
The goal of this clinical trial is to compare the quality of mesoangioblasts isolated from various patient groups suffering from muscle atrophy. This study includes cancer cachexia and muscle-impaired...
Detailed Description
No effective treatment is available for the loss of muscle tissue in non-genetic muscle diseases such as (cancer) cachexia and sarcopenia. Such a treatment would improve the quality of life, therapy s...
Eligibility Criteria
Inclusion
- Lung cancer cachexia:
- Diagnosed with NSCLC, stage III-IV
- Diagnosed with cachexia (\>5% unintentional body weight loss in past six months, \>2% body weight loss with BMI \<20, or skeletal muscle index for males \<7.26 kg/m2; females \<5.45 kg/m2)
- Age 50-60 or 60-70
- Written informed consent
- Patient group: MIE
- Scheduled for total hip, knee, or back surgery
- Age 60-70 or 70-80 year
- Written informed consent
- Controls
- Patients with scheduled knee-, hip-, and back surgery
- Age 50-60, 60-70, and 70-80 year
- Age and sex-matched to patient groups
- Written informed consent
Exclusion
- No filled-in IC
- Suffering from a muscular dystrophy or other disease known to affect muscle morphology or function
- Have a weekly alcohol intake of ≥ 35 units (men) or ≥ 24 units (women)
- Ongoing participation in other intervention clinical trials
- Major surgery of the muscle within 4 weeks of the visit unrelated to the study
- Patients unable and/or unwilling to comply with treatment and study instructions
- Any other factor that in the opinion of the investigator excludes the patient from the study
Key Trial Info
Start Date :
November 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06077734
Start Date
November 1 2023
End Date
November 1 2025
Last Update
October 11 2023
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