Status:
ACTIVE_NOT_RECRUITING
The Effects of Antibiotic Exposure in Early Infancy on Vaccine Responses
Lead Sponsor:
Landspitali University Hospital
Conditions:
Immune Responses
Antibiotic Treatment
Eligibility:
All Genders
Up to 6 years
Brief Summary
This prospective cohort study will include 200 term children born in Landspitali University Hospital in Iceland. The cohort will be divided into four groups according to antibiotic exposure of which o...
Detailed Description
This prospective cohort study will evaluate the development of the immune system by means of evaluating the immune responses to oral rotavirus vaccine and the scheduled childhood vaccinations in Icela...
Eligibility Criteria
Inclusion
- All term children born in Iceland from 2022-2023
Exclusion
- Children born with emergency caesarean section
- Children born before 36 weeks of gestation
- Children diagnosed with primary or secondary immunodeficiency
- Use of immunosuppressive drugs at recruitment or during the follow up period (excluding inhaled corticosteroids and short term oral corticosteroids (\<3 consecutive days).
- Children with chromosomal, genetic or other congenital diseases or abnormalities
- Children with severe, chronic diseases or disabilities
- Informed consent not signed by parents
Key Trial Info
Start Date :
September 10 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06079606
Start Date
September 10 2022
End Date
December 31 2027
Last Update
December 18 2025
Active Locations (1)
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1
Landspitali University Hospital
Reykjavik, Iceland, 101