Status:
COMPLETED
Human Mitochondrial Stress-driven Obesity Resistance
Lead Sponsor:
Rigshospitalet, Denmark
Collaborating Sponsors:
University of Copenhagen
Conditions:
Mitochondrial Diseases
Mitochondrial Myopathies
Eligibility:
All Genders
18+ years
Brief Summary
The overarching aim of this observational study is to determine alterations in energy balance while exploring the underlying cellular mechanisms in human genetic models of mitochondrial stress. In a ...
Detailed Description
Background: Pre-clinical models of mitochondrial stress are resistant to diet-induced obesity. Likewise, humans with primary mitochondrial diseases present a high prevalence of underweight (42%) as co...
Eligibility Criteria
Inclusion
- Eligibility criteria for individuals with mitochondrial DNA mutations
- Inclusion criteria:
- \- Known mtDNA point mutations
- Exclusion criteria:
- Use of antiarrhythmic medications or other medications which, in the opinion of the investigators, have the potential to affect outcome measures.
- Diagnosed severe heart disease, dysregulated thyroid gland conditions, or other dysregulated endocrinopathies, or other conditions which, in the opinion of the investigators, have the potential to affect outcome measures.
- Pregnancy
- Eligibility criteria for controls
- Exclusion criteria:
- Current and regular use of antidiabetic medications or other medications which, in the opinion of the investigators, have the potential to affect outcome measures.
- Diagnosed heart disease, symptomatic asthma, liver cirrhosis or -failure, chronic kidney disease, dysregulated thyroid gland conditions or other dysregulated endocrinopathies, or other conditions which, in the opinion of the investigators, have the potential to affect outcome measures
- Daily use of tobacco products
- Excessive alcohol consumption
- Pregnancy
Exclusion
Key Trial Info
Start Date :
October 20 2023
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 20 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06080568
Start Date
October 20 2023
End Date
December 20 2024
Last Update
June 22 2025
Active Locations (1)
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1
Rigshospitalet
Copenhagen, Denmark, Denmark, 2100