Status:
RECRUITING
Effect of Acute Exercise on Cognitive Functions and Blood Markers of Brain Plasticity in Regular Chronic Cannabis Users
Lead Sponsor:
University Hospital, Lille
Conditions:
Cannabis User
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The endocannabinoid system (ECS) is a complex endogenous signaling system made up of transmembrane cannabinoid receptors (CB1 and CB2 receptors), their endogenous lipid-derived ligands (the endocannab...
Eligibility Criteria
Inclusion
- Cannabis consumer group:
- Cannabis consumption \> 100 times in lifetime, last exposure \< 7 days, and recent exposure \> 10 times in the month.
- Positive toxicological urine test for ∆-9-THC.
- Having a cannabis use disorder according to the CAST.
- Healthy group:
- Negative urine toxicological test for cannabis.
- No regular cannabis use for more than 6 months once in a lifetime.
- No cannabis consumption in the 6 months preceding the study.
Exclusion
- For all subjects :
- Disorders of use of other substances (alcohol, cocaine, opioid, or synthetic drugs).
- Alcohol consumption greater than 30g per day (averaged over one week) and/or alcohol abuse the week preceding the visit.
- Under medical treatment.
- Presence of diagnosed neurological disorders.
- Diagnosis of a psychotic picture entering axis I, DSM-5.
- Chronic progressive disease or in remission.
- Body mass index \> 30 kg/m2 (i.e. presence of obesity).
Key Trial Info
Start Date :
May 7 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2029
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06081218
Start Date
May 7 2024
End Date
December 31 2029
Last Update
May 13 2025
Active Locations (1)
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1
CHU Lille
Lille, France, 59000