Status:
UNKNOWN
The Systemic Concentration of Short-Chain Fatty Acids After Delivery in the Small and Large Intestine of Healthy Volunteers
Lead Sponsor:
KU Leuven
Conditions:
Systemic Availability
Intestinal Absorption
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The goal of this crossover study is to evaluate the systemic availability of short-chain fatty acids (SCFA) that are either administered in the small intestine or the colon in healthy volunteers. The ...
Eligibility Criteria
Inclusion
- female and male
- healthy participants
- age within 18 - 50 years
- normal BMI (18.5-25 kg/m\^2)
Exclusion
- Chronic gastrointestinal disorders such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), celiac disease, chronic constipation (less than 3 stools a week) and chronic frequent diarrhoea (more than 3 stools a day)
- Previous abdominal surgery, except from appendectomy
- Being on a weight loss, gluten-free, lactose-free, or vegan diet
- The donation of blood during the last 3 months or suffering from low blood haemoglobin levels
- The use of antibiotics or other medication that affects the gastrointestinal tract 3 months preceding the study and/or during the study
- The use of prebiotics or probiotics 2 weeks preceding the study and/or during the study
- Pregnancy, lactation or wish to become pregnant during the study period
- Previous or current substance/alcohol dependence or abuse (\> 2 units per day/14 units per week)
Key Trial Info
Start Date :
October 9 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2024
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT06082726
Start Date
October 9 2023
End Date
May 1 2024
Last Update
October 16 2023
Active Locations (1)
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1
KU Leuven
Leuven, Belgium, 3000