Status:
UNKNOWN
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services
Lead Sponsor:
Great Ormond Street Hospital for Children NHS Foundation Trust
Collaborating Sponsors:
Murdoch Childrens Research Institute
The Hospital for Sick Children
Conditions:
Epilepsy
Eligibility:
All Genders
Up to 12 years
Brief Summary
Overall, this observational cohort study aims too: 1. Implement rapid trio WGS for all children presenting to our health systems with epilepsy onset under 12 months of age. 2. Utilize electronic heal...
Detailed Description
In the past decade, the genomic revolution has led to the identification of underlying genetic aetiologies for childhood epilepsy, in the form of monogenic disorders affecting ion channels, neurotrans...
Eligibility Criteria
Inclusion
- • Children under 12 months of age presenting with epilepsy.
Exclusion
- Simple febrile seizures.
- Acute or remote symptomatic seizures due to sepsis, haemorrhage, cerebral infarction, hypoxic ischaemic encephalopathy or non-accidental injury.
- Structural malformations of the brain where the likely genetic cause is known such as tuberous sclerosis or lissencephaly.
Key Trial Info
Start Date :
September 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT06082999
Start Date
September 1 2021
End Date
December 1 2025
Last Update
October 13 2023
Active Locations (4)
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1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
2
Murdoch Childrens Research Institute
Parkville, Victoria, Australia, 3052
3
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8
4
UCL Great Ormond Street Institute of Child Health
London, United Kingdom, WC1N 1DZ