Status:
ACTIVE_NOT_RECRUITING
Preventing Malaria in School Children to Protect the Whole Community in Rural Blantyre District, Malawi
Lead Sponsor:
Liverpool School of Tropical Medicine
Collaborating Sponsors:
Kamuzu University of Health Sciences
Conditions:
Malaria,Falciparum
Anemia in Children
Eligibility:
All Genders
6+ years
Phase:
PHASE4
Brief Summary
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with dihydroartemisinin-piperaquine...
Detailed Description
Students attending primary school in rural Blantyre District, Malawi will be offered enrollment in this study. The intervention will be conducted every 6-weeks during the school terms which coincide w...
Eligibility Criteria
Inclusion
- Student
- Currently enrolled in the study school
- Plan to attend the study school for the remainder of the school year
- Parent/guardian available to provide written informed consent
- Student
Exclusion
- Current evidence of severe malaria or danger signs
- Known adverse reaction to the study drugs
- History of cardiac problems or fainting
- Taking medications known to prolong QT
- Family history of prolonged QT
- History of epilepsy or psoriasis
- Taking cotrimoxazole for long-term prophylaxis
- Younger child Inclusion Criteria
- Slept in the household for most nights in the last month
- Age 6-59 months
- Parent/guardian available to provide written informed consent
- Younger child Exclusion Criteria
- \- Current evidence of severe malaria or danger signs
Key Trial Info
Start Date :
October 14 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT06083688
Start Date
October 14 2024
End Date
January 1 2026
Last Update
November 19 2025
Active Locations (1)
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1
Malaria Alert Centre
Blantyre, Malawi