Status:
RECRUITING
Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia
Lead Sponsor:
University of Aarhus
Conditions:
Hypotension
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
PHASE3
Brief Summary
The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs. phenylephrine infusion ...
Detailed Description
The brain and other blood flow sensitive organs are vulnerable to hypotension during neurosurgery. As a countermeasure, vasopressor agents are often administered to increase blood pressure. The ultima...
Eligibility Criteria
Inclusion
- Clinical diagnosis of supratentorial malignant or non-malignant brain tumors. Preferably 3 cm or larger( measured as the largest diameter in any plane on MRI).
- Scheduled for elective supratentorial craniotomy.
- Patients aged between 18 and 75 years.
- American Society of Anesthesiologists status 1-3
Exclusion
- History of allergy or intolerance to one of the study medications.
- Active treatment with monoamine oxidase inhibitors.
- An American Society of Anesthesiologists (ASA)physical status IV-VI.
- Pregnancy or breastfeeding.
- Inability to provide written informed consent -
Key Trial Info
Start Date :
December 20 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT06083948
Start Date
December 20 2023
End Date
December 31 2026
Last Update
January 6 2026
Active Locations (1)
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1
Aarhus University Hospital
Aarhus, Denmark, 8200