Status:
RECRUITING
Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration
Lead Sponsor:
Perceive Biotherapeutics, Inc.
Conditions:
Age-Related Macular Degeneration
Geographic Atrophy
Eligibility:
All Genders
60+ years
Phase:
PHASE1
PHASE2
Brief Summary
The Phase 1 safety study of VOY-101 comprises of escalating dose Cohorts, followed by a Phase 2a.
Detailed Description
This is a prospective, open-label, multi-center Phase 1/2a study to evaluate the safety of a single, unilateral intravitreal (IVT) injection of escalating dose levels of VOY-101 therapy in subjects wi...
Eligibility Criteria
Inclusion
- Are ≥60 years of age at the time of consent.
- Are willing and able to understand and provide written informed consent.
- Are willing and able to return for scheduled treatment and follow-up examinations.
- Are able to undergo ETDRS BCDVA testing and ophthalmic imaging.
- Well-demarcated GA secondary to AMD in the absence of MNV and in the absence of history of MNV for both eyes.
- Absence of signs of non-exudative MNV.
- Additional Ocular Inclusion Criteria for both eyes.
- Meet certain genotype criteria for risk of AMD.
Exclusion
- Are women of childbearing potential (WOCBP) and are pregnant or unwilling to use and document use of effective contraception for the duration of the study.
- Additional Systemic, Ocular, and Genetic Exclusion Criteria.
Key Trial Info
Start Date :
June 21 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2028
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT06087458
Start Date
June 21 2023
End Date
March 1 2028
Last Update
October 15 2025
Active Locations (11)
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1
Retina Macula Institute of AZ
Scottsdale, Arizona, United States, 85255
2
The Retina Partners
Encino, California, United States, 91436
3
Retinal Consultants Medical Group
Sacramento, California, United States, 95825
4
Retina Consultants San Diego
San Diego, California, United States, 92064