Status:
UNKNOWN
Fingolimod in Minimal Invasive Treatment of Intracerebral Hemorrhage
Lead Sponsor:
Tang-Du Hospital
Conditions:
Intracerebral Hemorrhage
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
PHASE2
Brief Summary
Intracerebral hemorrhage (ICH) is a critical disease of public health importance. Inflammatory mechanisms play a significant role in ICH. Thus, immune targets are supposed to be effective in protectin...
Detailed Description
40 ICH patients who meet the inclusion criteria will be enrolled in the present study. All ICH patients will be screened. If meeting the including criteria, the investigators will contact the family,...
Eligibility Criteria
Inclusion
- spontaneous basal ganglia ICH with volume larger than 20ml;
- age: 18-80 years;
- admission Glasgow Coma Scale score: 5-12;
- admitting to hospital with 24 hours after injury;
- no fever or signs infection on admission to hospital;
- admission heart rate≥60/min on admission.
Exclusion
- refuse follow-up;
- received operation before admitting to hospital;
- hemorrhage by tumor, arteriovenous malformation, arterial aneurysm, hematological disease or traumatic brain injury;
- severe vomiting;
- mRS\>1 before ICH;
- prior history of bradycardia;
- prior history of Atrioventricular block;
- prior history of traumatic brain injury, craniotomy or stroke;
- expected lifetime less than 1 year;
- undergoing antitumor, antiepileptic, immunomodulatory or immunosuppressive therapy;
- admitting to other ongoing study;
- systemic disease: uremia, liver cirrhosis, malignant tumor, mental disease, drug or alcohol dependence;
- received anticoagulant or antiplatelet therapy within 7 days;
- intraventricular hemorrhage requires intraventricular catheterization.
Key Trial Info
Start Date :
October 11 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06087965
Start Date
October 11 2023
End Date
December 30 2025
Last Update
October 18 2023
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