Status:
UNKNOWN
Efficacy of Amoxicillin-Esomeprazole HDDT Compared to Levofloxacin Triple Therapy for H. Pylori Eradication: A RCT
Lead Sponsor:
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Conditions:
Helicobacter Pylori Infection
Helicobacter Pylori Eradication
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The goal of this clinical trial is to compare the efficacy of two different therapeutic regimen for the treatment of Helicobacter pylori infected dyspeptic patients. The aim is - 1. To identify the p...
Detailed Description
Introduction: Helicobacter pylori infection is one of the most common infections worldwide and represents a major cause of gastritis, gastric and duodenal ulcers, mucosa-associated lymphoid tissue ly...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Dyspeptic patients with positive Rapid urease test \& stool antigen test
- patients giving written informed consent
Exclusion
- Treatment with proton pump inhibitor, H2-receptor antagonist, bismuth preparation within the last 2 weeks or antibiotics within 4 weeks prior to study.
- Previous H. pylori eradication therapy
- Complicated duodenal ulcer patients (active bleeding and perforation)
- Patients with regular intake of NSAIDs or steroids.
- Surgery that might affect gastric acid secretion (upper GI resection or vagotomy)
- Known case of malignancy
- Advanced Co-morbidities (e.g. CLD, CKD, cardio-respiratory failure, known thyroid disease)
- participants who are pregnant, lactating or intend to become pregnant within the duration of the study.
Key Trial Info
Start Date :
February 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2024
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT06088316
Start Date
February 10 2023
End Date
February 1 2024
Last Update
October 18 2023
Active Locations (1)
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1
Bangabandhu sheikh mujib medical university
Dhaka, Bangladesh, 1000