Status:
RECRUITING
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Lead Sponsor:
The University of Hong Kong
Conditions:
Obstructive Sleep Apnea
Mild Cognitive Impairment
Eligibility:
All Genders
18+ years
Brief Summary
Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and leads to cardiometa...
Detailed Description
Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation. Chronic intermittent h...
Eligibility Criteria
Inclusion
- Aged 18 years and above
- Clinical diagnosis of mild cognitive impairment (MCI) based on Petersen's criteria. The criteria include the following: (1) memory problems, (2) objective memory disorder, (3) absence of other cognitive disorders or repercussions on daily life, (4) normal general cognitive function and (5) absence of dementia OR,
- Diagnosis of subjective cognitive impairment, based on the subject's own complaint of cognitive impairment but with an unremarkable assessment of the Hong Kong version of Montreal Cognitive Assessment scores
- Able to speak and read Chinese
- Adequate visual and auditory to perform a cognitive test
Exclusion
- Diagnosed psychiatric illness with or without medication, e.g. major depressive disorder.
- Other clear organic causes of cognitive impairment, e.g. old stroke, brain tumour, dementia with Lewy body, Parkinson's disease, normal pressure hydrocephalus, neurosyphilis, autoimmune encephalitis, substance abuse, history of alcohol abuse.
- Diagnosis of major unstable illness or cancer on active treatment
- Unable to perform Home Sleep Apnea Test
- Those patients who require legal guardians
Key Trial Info
Start Date :
March 7 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 31 2027
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT06089096
Start Date
March 7 2023
End Date
March 31 2027
Last Update
April 2 2025
Active Locations (1)
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1
Queen Mary Hospital
Hong Kong, Hong Kong