Status:
RECRUITING
Virtual Home-based Physical Pre-habilitation in Kidney Transplant Candidates
Lead Sponsor:
McGill University Health Centre/Research Institute of the McGill University Health Centre
Collaborating Sponsors:
The Kidney Foundation of Canada
Conditions:
Kidney Disease, End-Stage
Frailty
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this RCT is to address the feasibility of conducting a 12-week virtual pre-habilitation intervention, which includes exercise and education, in kidney transplant candidates. The interventi...
Detailed Description
While waiting for kidney transplant, candidates face many challenges related to their physical health. These physical impairments are strongly associated with pre- and post-transplant mortality and mo...
Eligibility Criteria
Inclusion
- consecutive individuals with end stage kidney disease (ESKD) (aged ≥18 years), classified as pre-frail (1-2 points), frail (3-4 points) or very frail (5 points) on the Fried's frailty phenotype and who are accepted or in the process of being accepted to enter in the deceased or living donor KT waiting list of the McGill University Health Centre (MUHC), Centre Hospitalier de l'Université de Montreal (CHUM) or University of Alberta Hospital (UAH) for first-time transplantation or re-transplantation
- English or French speakers
- is technologically capable of connecting (either independently or through household members/next-of-kin) with an online videoconferencing platform through an e-mail invitation (Patients who do not have access to internet will borrow a tablet with internet for the period of the study)
Exclusion
- Individuals who:
- are classified as robust (0 points) on their Fried's frailty phenotype score
- are participating in a structured exercise program (hospital-based or home-based or another trial)
- are waiting for kidney-pancreas or kidney-liver transplant as those have much longer waiting time
- are hospitalized for any reason during the assessment for eligibility
- have a cPRA (calculated panel reactive antibodies) \>95% and are on the highly sensitized exchange program and expected to have a prolonged waiting times on the waiting list
- are expected to have a transplant before the end of the 12 week-intervention (e.g. individuals who will receive an organ from a living donor or are type A blood
- have pre-existing or newly identified significant cognitive impairment
- have pre-existing or newly identified cardiac, musculoskeletal, neuropathy or neurological condition that might affect their exercise performance or otherwise render rehabilitation participation unsafe
Key Trial Info
Start Date :
November 2 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06089473
Start Date
November 2 2024
End Date
February 1 2027
Last Update
December 3 2025
Active Locations (2)
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1
Centre de recherche - Centre Hospitalier de l'Université de Montréal (CRCHUM)
Montreal, Quebec, Canada, H2X 0A9
2
Research Institute - McGill University Health Centre (RI-MUHC)
Montreal, Quebec, Canada, H4A 3J1