Status:
RECRUITING
MARINER Trial: Multiparametric Cardiac PET for CAV Surveillance After Heart Transplantation
Lead Sponsor:
Ottawa Heart Institute Research Corporation
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Cardiac Allograft Vasculopathy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cardiac allograft vasculopathy (CAV) is a common complication affecting heart transplant patients. This condition causes narrowing of the heart arteries leading to graft dysfunction. Surveillance for ...
Detailed Description
MARINER is a Canadian multicentre prospective, randomized clinical outcomes-based trial evaluating noninferiority of a noninvasive PET strategy compared to ICA for CAV surveillance. Patients are rando...
Eligibility Criteria
Inclusion
- Post heart transplant 2-10 years.
- Age ≥18 years.
- Able to provide informed consent.
Exclusion
- Contraindication to dipyridamole due to severe aortic stenosis.
- Contraindication to dipyridamole due to 2:1 or greater AV block without pacemaker.
- Contraindication to dipyridamole due to severe bronchospasm.
- Unable to undergo coronary angiography due to allergy to iodinated contrast.
- Unable to undergo coronary angiography due to glomerular filtration rate ≤30 mL/min/1.73 m2. for non-dialysis patients as determined by local laboratory analysis.
- Unable to undergo coronary angiography due to unsuitable vascular access.
- Treated rejection ≤1-month.
- Unstable angina or MI ≤7 days.
Key Trial Info
Start Date :
January 8 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2029
Estimated Enrollment :
576 Patients enrolled
Trial Details
Trial ID
NCT06089486
Start Date
January 8 2024
End Date
March 1 2029
Last Update
April 3 2025
Active Locations (5)
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1
University of Calgary
Calgary, Alberta, Canada
2
Mazankowski Alberta Heart Institute
Edmonton, Alberta, Canada
3
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7
4
Toronto-General Hospital - University Health Network
Toronto, Ontario, Canada