Status:
UNKNOWN
Effects of Peripheral Electrical Stimulation With Focused Ultrasound on Motor Symptoms in Parkinson's Patients
Lead Sponsor:
University Health Network, Toronto
Conditions:
Parkinson Disease
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation(NIBS) technique that can be used on both superficial and deep brain targets with a high spatial resolution as sm...
Detailed Description
There are 3 study visits and for all of them patients will remain in ON dopaminergic medication condition. Each visit will be a minimum of 7 days apart. Each visit will contain 1 of 3 combinations: ...
Eligibility Criteria
Inclusion
- 18-90 years of age
- Confirmed diagnosis of Parkinson's disease
- Stable dopaminergic medication dose for a minimum of 4 weeks (applicable for PD patients only)
Exclusion
- History of stroke or seizure
- Comorbid dementia
- Scored below 22 on the Montreal Cognitive Assessment (MoCA)
- Has intracranial implant(s) or device(s)
- Has an implanted cardiac pacemaker or implantable cardioverter-defibrillator (ICD)
- Has a previous surgical intervention to treat the movement disorder such as lesioning or a Deep Brain Stimulation system in place.
- Presence of metal implanted in body that is contraindicated in TMS/MRI/peripheral electrical stimulation
- Pregnancy
- Major depression/psychiatric disorder that in the opinion of the Investigator will affect patient's understanding of study procedures and willingness to abide by all procedures during the course of the study
- Is on antipsychotics, anti-depressants, marijuana, or other recreational drugs that affect the nervous system
- Major musculoskeletal or neuromuscular disease or disorder of the hands, wrists and limbs
- Severe Dyskinesia
- Genetic mutations
- Major systemic illness or infection
Key Trial Info
Start Date :
June 13 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 13 2025
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT06090292
Start Date
June 13 2023
End Date
June 13 2025
Last Update
October 19 2023
Active Locations (1)
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1
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8