Status:
RECRUITING
Effect and Mechanism of Brain Stimulation for Parkinson's Disease With Cognitive Impairment
Lead Sponsor:
Tianjin Huanhu Hospital
Conditions:
Parkinson Disease
Cognitive Impairment
Eligibility:
All Genders
Up to 75 years
Brief Summary
This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patien...
Detailed Description
A variety of post-processing methods (VBM, SPM, CAT, LEAD-DBS, etc.) were used to analyze structural brain network images (sMRI, DTI) and functional brain network images (rs-fMRI, PET) based on connec...
Eligibility Criteria
Inclusion
- 1\. The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS.
Exclusion
- Exclusion criteria included patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery.
Key Trial Info
Start Date :
November 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2027
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06090682
Start Date
November 1 2023
End Date
November 1 2027
Last Update
October 19 2023
Active Locations (1)
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1
Tianjin Huanhu Hospital
Tianjin, Tianjin Municipality, China, 300070