Status:
RECRUITING
Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma
Lead Sponsor:
Jonsson Comprehensive Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Glioblastoma
Recurrent Glioblastoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This clinical trial uses a type of imaging scan called magnetic resonance imaging (MRI) to study brain tumor biology in patients with glioblastoma that can be removed by surgery (resectable). Malignan...
Detailed Description
PRIMARY OBJECTIVES: I. Enhancing tumors with high diffusion measurements (low apparent diffusion coefficient \[ADCL\] \> 1.24 um\^2/ms) will have higher DCN protein expression compared with tumors ex...
Eligibility Criteria
Inclusion
- Patients \> 18 years of age
- Patients with newly diagnosed, suspected or recurrent glioblastoma (GBM) patients with enhancing tumors greater than 1.5 mL clinically indicated for surgical resection. Recurrent GBM must have occurred more than 3 months after the end of radiation therapy per Response Assessment in Neuro-Oncology Criteria (RANO) guidelines
Exclusion
- Counterindication to magnetic resonance imaging (MRI) (Patient has a pacemaker or metal in the body)
- Patients \< 18 years of age
Key Trial Info
Start Date :
April 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 18 2028
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06090903
Start Date
April 14 2022
End Date
April 18 2028
Last Update
November 10 2025
Active Locations (1)
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1
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States, 90095