Status:
COMPLETED
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder (TPIP) in Healthy Participants
Lead Sponsor:
Insmed Incorporated
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
Brief Summary
The primary purpose of this study is to evaluate the safety and tolerability of single and multiple doses of treprostinil palmitil inhalation powder in healthy participants.
Eligibility Criteria
Inclusion
- The participant is considered by the investigator to be in good general health as determined by medical history, physical examination findings, vital sign measurements, 12-lead electrocardiogram (ECG) results, and clinical laboratory test results within normal limits or considered not clinically significant by the investigator, at screening.
Exclusion
- The participant has an allergy, documented hypersensitivity, or contraindication to the ingredients or to any of the excipients of treprostinil palmitil inhalation powder or treprostinil.
- The participant has used any prescription (excluding hormonal birth control) or over-the-counter medications, including herbal or nutritional supplements, within 14 days before the first dose of study drug and throughout the study.
- The participant has a history of anaphylaxis, previously documented hypersensitivity reaction to any drug.
- The participant has had a surgical procedure that required general anesthesia (or equivalent) within 90 days prior to screening.
- The participant has a body mass index \<19.0 or \>32.0 kilograms per square meter (kg/m\^2) at screening.
- The participant has a history of syncope not due to dehydration or vasovagal syncope (eg, congenital cardiac arrhythmias such as Wolff-Parkinson-White syndrome, nodal tachycardia, ventricular tachycardia, etc).
- The participant has active liver disease or hepatic dysfunction at screening or check-in visits.
- The participant has a history of human immunodeficiency virus (HIV) infection.
- The participant has a history of abnormal bleeding or bruising.
- The participant has a history of malignancy in the past 5 years, with exception of nonmelanoma skin cancer.
- The participant has a current history (within the past 12 months) of substance and/or alcohol abuse.
- The participant is a current user of cigarettes (average of ≥1 cigarette/day) or e-cigarettes within 30 days prior to screening.
- The participant has a positive test result for drugs of abuse, alcohol, or cotinine (indicating active current smoking) at screening or before the first dose of study drug or throughout the study.
- Note: Other inclusion/exclusion criteria may apply.
Key Trial Info
Start Date :
September 17 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 12 2021
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT06091579
Start Date
September 17 2020
End Date
January 12 2021
Last Update
October 19 2023
Active Locations (1)
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1
USA001
Austin, Texas, United States, 78744