Status:
COMPLETED
Imaging of Chemotherapy-induced Morphological and Functional Lung Changes in Childhood ALL and HD
Lead Sponsor:
University of Erlangen-Nürnberg Medical School
Conditions:
Acute Lymphoblastic Leukemia
Hodgkin Disease
Eligibility:
All Genders
5-17 years
Phase:
NA
Brief Summary
With increasing cure rates of childhood cancer there is growing recognition of late effects of treatments. However, there is a lack of non-invasive and child-friendly procedures that can indicate poss...
Detailed Description
With increasing cure rates of childhood cancer there is growing recognition of late effects of treatments. However, there is a lack of non-invasive and child-friendly procedures that can indicate poss...
Eligibility Criteria
Inclusion
- Study arm: "Early therapeutic effects"
- Diagnosed acute lymphatic leukemia or Hodgkin's disease (HD)
- Completed induction therapy or radiotherapy
Exclusion
- Pregnancy, Lactation
- Known pleural or pericardial effusion
- Critical condition (requiring respiratory support, ventilation, oxygen, shock, symptomatic heart failure)
- Marked thoracic deformities/malformations
- Previous lung surgery
- Injuries that do not allow physical stress diagnostics
- Rejection of MRI imaging
- General contraindications for MRI examinations (e.g. electrical implants such as cardiac pacemakers or perfusion pumps, etc.)
- Study arm: "Late therapeutic effects"
- Inclusion Criteria:
- Diagnosed acute lymphatic leukemia or Hodgkin's disease (HD)
- Completed intensive therapy or radiotherapy
Key Trial Info
Start Date :
October 17 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 9 2024
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT06093334
Start Date
October 17 2023
End Date
December 9 2024
Last Update
December 17 2024
Active Locations (1)
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1
Department of Pediatrics and Adolescent Medicine
Erlangen, Bavaria, Germany, 91054