Status:
RECRUITING
The Use of Thrombin Generation Assay in Detection of Central Line Related Thrombosis (CRT) in Critically Ill Patients
Lead Sponsor:
Queen Mary Hospital, Hong Kong
Conditions:
Central Line Complication
Thrombosis, Venous
Eligibility:
All Genders
18-100 years
Brief Summary
To study thrombin generation parameters in critically ill patients with and without central line related thrombosis (CRT).
Eligibility Criteria
Inclusion
- Age ≧ 18; AND
- Admitted to the mixed medical-surgical intensive care units of Queen Mary Hospital in Hong Kong; AND
- Clinically indicated for central catheter insertion, which includes central venous catheters and dialysis catheters; AND
- Expected to have the central catheter in place for at least 5 days in their ICU stay.
Exclusion
- Patients known to have active venous thromboembolism including deep venous thrombosis or pulmonary embolism;
- Patients known to have hypercoagulable states, e.g., hereditary thrombophilia, antiphospholipid syndrome; OR
- Patients with active solid organ or hematological malignancies; OR
- Patients already receiving therapeutic anticoagulation prior to study recruitment; OR
- Patients with thrombosis detected in the insertion site before central catheter insertion; OR
- Patients with a central venous catheter already in place prior to ICU admission; OR
- Patients admitted to the ICU for post-operative care; OR
- Patients admitted to the ICU for trauma care; OR
- Patients requiring extra-corporeal life support (ECLS); OR
- Patients with poor window or inaccessible for ultrasonographic examination; OR
- Pregnancy/post-partum within 6 weeks
Key Trial Info
Start Date :
April 6 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06094387
Start Date
April 6 2024
End Date
April 1 2025
Last Update
April 9 2024
Active Locations (1)
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1
Queen Mary Hospital
Hong Kong, Hong Kong