Status:
RECRUITING
CTV Delineation Based Solely on Geometric Expansion From GTV in Nasopharyngeal Carcinoma
Lead Sponsor:
Fujian Cancer Hospital
Conditions:
Nasopharyngeal Carcinoma by AJCC V8 Stage
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
This is a randomized, phase III, prospective, multi-center trial in newly diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis. The aim of this study is to evaluate the efficac...
Detailed Description
All enrolled patients underwent intensity-modulated radiation therapy (IMRT). The IMRT technique was selected based on the equipment available at each treatment center and the patients' preferences, i...
Eligibility Criteria
Inclusion
- Pathologic diagnosis (pathologically confirmed by nasopharyngeal biopsy) was nasopharyngeal carcinoma;
- No distant metastatic;
- Patients with baseline MRI date of nasopharynx and neck, and completed the first course of treatment in our hospital;
- Eastern Cooperative Oncology Group (ECOG) score of 0 or 1;
- Signing informed consent;
- Follow up regularly and comply with test requirements.
Exclusion
- Disease progression during IMRT;
- Previous malignancy or other concomitant malignant diseases;
- The evaluation information of tumor efficacy can not be obtained;
- Receive blind treatment in other clinical research;
- Have or are suffering from other malignant tumors within 5 years (except non- melanoma skin cancer or pre-invasive cervical cancer);
- Serious complications, such as uncontrolled hypertension, coronary heart disease, diabetes, heart failure, etc;
- Active systemic infection;
- No or limited capacity for civil conduct;
- The patient has a physical or mental disorder, and the researcher considers that the patient is unable to fully or fully understand the possible complications of this study;
- Pregnancy or lactation period;
Key Trial Info
Start Date :
January 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2030
Estimated Enrollment :
474 Patients enrolled
Trial Details
Trial ID
NCT06095154
Start Date
January 1 2025
End Date
December 31 2030
Last Update
March 13 2025
Active Locations (1)
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1
Fujian Cancer hospital
Fuzhou, Fujian, China, 351100