Status:
UNKNOWN
Gliflozins on HF in Regurgitant Rheumatic Heart
Lead Sponsor:
Assiut University
Conditions:
Rheumatic Heart Disease
Heart Failure
Eligibility:
All Genders
18+ years
Brief Summary
The objective of this trial is to detect impact of Gliflozin on patients with heart failure due to reurgitant rheumatic valve disease
Detailed Description
* Rheumatic heart disease is a chronic sequel of acute rheumatic fever caused by group A β hemolytic Streptococcal pharyngitis and possibly pyoderma, which mimics molecular heart structures so the imm...
Eligibility Criteria
Inclusion
- All male or female patients having rheumatic heart disease with either mitral, aortic, tricuspid regurge as a single or combined valvular lesion
- Patients aged 18 years or older at time of inclusion in the study
- Patients with HF currently in NYHA class II-IV, or asymptomatic patients with proved mitral regurgitant lesion.
- Body Mass Index (BMI) \< 45 kg/m2
Exclusion
- Advanced stage liver and kidney failure (glomerular filtration rate \< 20 mL/min/1.73 m2).
- Patient with implanted cardiac pacemaker, implantable cardioverter-defibrillator (ICD) or cardiac re-synchronization therapy (CRT) or implanted left ventricular assist device (LVAD)
- Diagnosis of cardiomyopathy induced by other etiologies rather than rheumatic heart disease eg, ischemia , dilated cardiomyopathy,…..etc within the 12 months prior to Visit 1
- Known allergy or hypersensitivity to SGLT-2 inhibitors
- Women who are pregnant, nursing, or who plan to become pregnant while in the trial
- ongoing hematological diseases and malignancies
Key Trial Info
Start Date :
December 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2025
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06097585
Start Date
December 1 2023
End Date
April 1 2025
Last Update
October 30 2023
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