Status:
COMPLETED
Dexmedetomidine and Propofol in Mechanically Ventilated Patients by Using Salivary Alpha-amylase as a Stress Marker
Lead Sponsor:
Tanta University
Conditions:
Dexmedetomidine
Propofol
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The aim of this study is to compare the efficacy of dexmedetomidine and propofol on decreasing stress in mechanically ventilated patients by using salivary alpha-amylase as a stress marker.
Detailed Description
Critically ill patients receiving mechanical ventilation (MV) in the Intensive Care Unit (ICU) have been reported to suffer due to their sense of dependency on technical medical equipment and from sev...
Eligibility Criteria
Inclusion
- Age 18 to 65 years old.
- Both sexes.
- Newly mechanically ventilated.
Exclusion
- Patients who used inhaled steroids.
- Patients who used any medication that could affect salivary glands (such as antihypertensive, antidepressants or antipsychotic drugs).
- Those with smoking and drinking habits.
- Patients on adrenoreceptor agonist or antagonist therapy.
- Pregnant female.
- Known hypersensitivity to the study drugs.
- Women using oral contraceptive or were in their menstrual cycle.
Key Trial Info
Start Date :
October 24 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 11 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06098209
Start Date
October 24 2023
End Date
April 11 2024
Last Update
May 14 2024
Active Locations (1)
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1
Tanta University
Tanta, El-Gharbia, Egypt, 31527