Status:
RECRUITING
MIMA Pilot Study: MIcrostructure of the Medial Temporal Lobe in Early Alzheimer's Disease
Lead Sponsor:
Rennes University Hospital
Conditions:
Alzheimer Disease, Early Onset
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
Patients with Mild Cognitive Impairment (MCI) or Subjective Cognitive Decline (SCD) may or may not develop Alzheimer's disease (AD) dementia. Yet identifying patients at risk is crucial: delaying the ...
Detailed Description
The study will combine multi-compartment models (e.g. Archer et al., 2020; Parker et al., 2020) of high-resolution diffusion MRI within medial temporal lobes regions of interest defined through the AS...
Eligibility Criteria
Inclusion
- aged between 50 and 80
- native French speaking
- right-handed
- with a level of education equal to or higher than the Certificat d'Etudes Primaires (primary school leaving certificate)
- free of any medical or psychiatric condition likely to interfere with cognition, other than a diagnosis of SCD / MCI
- affiliated with a social security scheme
- having received oral and written information abou the protocol and having signed a consent form to participate in this research
- patients with 'subjective cognitive decline-plus' (hereafter 'SCD', criteria of Jessen et al., 2014) or patients with mild neurocognitive impairment due to Alzheimer's disease (hereafter 'MCI', criteria of Albert et al., 2011)
Exclusion
- contraindications to MRI : Abdominal circumference + upper limbs stuck to the body \> 200 cm; Implantable pacemaker or defibrillator; Neurosurgical clips; Cochlear implants ; Neural or peripheral stimulator; Intra-orbital or encephalic metallic foreign bodies; Endoprostheses fitted less than 4 weeks ago and osteosynthesis devices fitted less than 6 weeks ago; Claustrophobia.
- sensory deficit interfering with experimental tests
- pregnant or breast-feeding women
- adults under legal protection (safeguard of justice, curatorship, guardianship), persons deprived of liberty
- 7-items modified Hachinski ischemic score \>2 (Hachinski et al., 2012)
- Dementia (McKhann et al., 2011)
Key Trial Info
Start Date :
July 2 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06099587
Start Date
July 2 2024
End Date
March 1 2027
Last Update
July 8 2024
Active Locations (1)
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1
CHU Rennes
Rennes, France