Status:
UNKNOWN
Study on the Mechanism of Immune Inflammation in Cognitive Impairment of Depression
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University
Conditions:
Depression
Eligibility:
All Genders
18-60 years
Brief Summary
The patients with depression were observed and followed up to evaluate the changes of symptoms and cognitive function in patients with depression at different time points before and after drug treatme...
Detailed Description
1. Participants were included according to the inclusion and exclusion criteria, and demographic data of depressed patients and healthy controls were recorded, including age, sex, ethnicity, occupatio...
Eligibility Criteria
Inclusion
- Age 18-60 years old, male or female;
- Meet the diagnostic criteria for depression in the International Classification of Diseases-10 (ICD-10), and the Hamilton Depression Scale (HAMD) score ≥18 points;
- Junior high school education and above, can cooperate with the completion of relevant scales and sample collection;
- did not receive antidepressant therapy at admission or took medication for less than 14 days; And the duration of drug withdrawal ≥3 months;
- No history of infection and taking hormones, antibiotics or anti-inflammatory drugs in the past 1 month;
- History of physical diseases such as centerless, liver, kidney and gastrointestinal tract, active infection, active or chronic inflammation, autoimmune diseases, etc.
Exclusion
- Pregnant and lactating women;
- Clinically significant or unstable medical conditions, including congestive heart failure, liver and kidney failure, cancer, immune and metabolic endocrine diseases;
- Patients with acute or chronic infection, taking anti-inflammatory drugs, cortisol hormones, and receiving antibiotics for 3 consecutive days in the past 1 month;
- Patients with neuropsychiatric diseases other than depression.
Key Trial Info
Start Date :
July 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2025
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT06100302
Start Date
July 1 2022
End Date
February 1 2025
Last Update
October 25 2023
Active Locations (1)
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1
277 Yanta West Road
Xi'an, Yanta, China, 710061