Actively Recruiting
Study of Subcutaneous Risankizumab Compared to Adalimumab in Children With Active Juvenile Psoriatic Arthritis to Assess Safety, Disease Activity, and Drug Behavior
Led by AbbVie · Updated on 2026-05-13
40
Participants Needed
32
Research Sites
220 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Juvenile psoriatic arthritis (jPsA) is a type of arthritis that starts before age 16 and occurs when the immune system attacks healthy cells causing joint pain, stiffness, and swelling. This research aims to evaluate the safety of risankizumab for treating jPsA and to observe changes in disease symptoms. The study compares risankizumab with adalimumab, an approved treatment for jPsA, in a phase 3 clinical trial involving approximately 40 children worldwide. Participants are randomly assigned to receive either risankizumab or adalimumab as subcutaneous injections based on their body weight. The first period lasts 24 weeks, during which the assigned treatment is given. Those who respond to their treatment continue the same medication for an additional 100 weeks in the second period. If symptoms worsen during this time, participants may be withdrawn. After treatment ends, safety follow-up lasts 70 days for adalimumab and 140 days for risankizumab recipients. Throughout the study, participants attend regular visits at clinics or hospitals where medical assessments, blood tests, and questionnaires are used to monitor treatment effects and side effects. Researchers will measure improvement in arthritis symptoms and record any adverse events up to 144 weeks. The total study involvement can last over two years, including treatment and follow-up periods.
CONDITIONS
Official Title
A Study to Assess Adverse Events, Change in Disease Activity, and How the Drug Moves Through the Body in Children With Juvenile Psoriatic Arthritis (jPsA) Receiving Subcutaneously Injected Risankizumab or Adalimumab
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of juvenile psoriatic arthritis for at least 3 months before screening
- Active disease in 3 or more joints at screening and baseline
- Inadequate response or intolerance to at least one conventional synthetic disease-modifying antirheumatic drug (methotrexate, sulfasalazine, leflunomide, or hydroxychloroquine)
You will not qualify if you...
- Presence of other autoimmune or rheumatic diseases or overlap syndromes
- Previous inadequate response to anti-TNF or IL-23 inhibitor treatments
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 32 locations
1
Arkansas Children's Hospital /ID# 258776
Little Rock, Arkansas, United States, 72202
Actively Recruiting
2
Childrens National Medical Center /ID# 259284
Washington D.C., District of Columbia, United States, 20010-2916
Actively Recruiting
3
Joe Dimaggio Children's Hospital Hollywood /ID# 260634
Hollywood, Florida, United States, 33021
Actively Recruiting
4
Indiana University Health Riley Hospital for Children /ID# 259067
Indianapolis, Indiana, United States, 46202
Actively Recruiting
5
M Health Fairview University of Minnesota Medical Center - West Bank /ID# 260111
Minneapolis, Minnesota, United States, 55454
Actively Recruiting
6
Columbia University Medical Center /ID# 262587
New York, New York, United States, 10032-3729
Actively Recruiting
7
Boston Childrens Health Physicians /ID# 258061
Valhalla, New York, United States, 10595
Actively Recruiting
8
University of North Carolina - Children's Hospital /ID# 259286
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
9
MetroHealth Medical Center /ID# 262377
Cleveland, Ohio, United States, 44109
Actively Recruiting
10
Child Neurology Consultants of Austin /ID# 260562
Austin, Texas, United States, 78757-7571
Actively Recruiting
11
Monash Health - Monash Medical Centre /ID# 260255
Clayton, Victoria, Australia, 3168
Actively Recruiting
12
Alberta Children's Hospital /ID# 257880
Calgary, Alberta, Canada, T3B 6A8
Actively Recruiting
13
British Columbia Children and Women's Hospital and Health Centre /ID# 257884
Vancouver, British Columbia, Canada, V6H 3N1
Actively Recruiting
14
Hospital for Sick Children /ID# 257879
Toronto, Ontario, Canada, M5G 1X8
Actively Recruiting
15
CHU Bordeaux - Hopital Pellegrin /ID# 258729
Bordeaux, New Aquitaine, France, 33076
Actively Recruiting
16
AP-HP - Hopital Bicetre /ID# 258728
Le Kremlin-Bicêtre, Paris, France, 94270
Actively Recruiting
17
Asklepios Klinik Sankt Augustin /ID# 259106
Sankt Augustin, North Rhine-Westphalia, Germany, 53757
Actively Recruiting
18
Helios Klinikum Berlin - Buch /ID# 268803
Berlin, Germany, 13125
Actively Recruiting
19
Hamburger Zentrum fuer Kinder- und Jugendrheumatologie /ID# 259104
Hamburg, Germany, 22081
Actively Recruiting
20
Azienda Ospedaliero Universitaria Meyer /ID# 258587
Florence, Firenze, Italy, 50139
Actively Recruiting
21
ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO /ID# 276753
Milan, Milano, Italy, 20122
Actively Recruiting
22
Ospedale Pediatrico Bambino Gesù /ID# 258869
Rome, Roma, Italy, 00165
Actively Recruiting
23
Malopolskie Badania Kliniczne /ID# 258777
Cracow, Lesser Poland Voivodeship, Poland, 30-002
Actively Recruiting
24
Uniwersytecki Szpital Dzieciecy w Lublinie /ID# 258781
Lublin, Lublin Voivodeship, Poland, 20-093
Actively Recruiting
25
Narodowy Instytut Geriatrii, Reumatologii I Rehabilitacji /ID# 277050
Warsaw, Masovian Voivodeship, Poland, 02-637
Actively Recruiting
26
Centrum Zdrowia Dziecka i Rodziny im Jana Pawla II w Sosnowcu /ID# 277058
Sosnowiec, Silesian Voivodeship, Poland, 41-200
Actively Recruiting
27
SPZOZ Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi /ID# 258785
Lodz, Łódź Voivodeship, Poland, 91-738
Actively Recruiting
28
Hospital Sant Joan de Deu /ID# 257568
Esplugues de Llobregat, Barcelona, Spain, 08950
Actively Recruiting
29
Hospital Universitario y Politecnico La Fe /ID# 257567
Valencia, Spain, 46026
Actively Recruiting
30
Sheffield Children's Hospital NHS Foundation Trust /ID# 258848
Sheffield, England, United Kingdom, S10 2TH
Actively Recruiting
31
University Hospitals Bristol and Weston NHS Foundation Trust /ID# 258847
Bristol, United Kingdom, BS2 8BJ
Actively Recruiting
32
Alder Hey Children's NHS Foundation Trust /ID# 262770
Liverpool, United Kingdom, L12 2AP
Actively Recruiting
Research Team
A
ABBVIE CALL CENTER
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here