Status:
ENROLLING_BY_INVITATION
A Multicenter Phenotype-Genotype Analysis of DM1 Patients in China
Lead Sponsor:
Huashan Hospital
Conditions:
Myotonic Dystrophy 1
Eligibility:
All Genders
18-80 years
Brief Summary
Myotonic dystrophy 1 (DM1) is an autosomal, dominantly inherited neuromuscular disorder characterized by skeletal muscle weakness, myotonia, cardiac conduction abnormalities, cataracts, and other abno...
Detailed Description
This multicenter, prospective, observational study investigates the diagnosis and progression of Myotonic Dystrophy Type 1 (DM1) in Chinese patients through comprehensive data collection. The research...
Eligibility Criteria
Inclusion
- Age between 18-80 years
- With enough cognitivie ability to understand the content and sign the informed consent form
- With CTG repeats \>50 in DMPK gene, revealed by PCR test
Exclusion
- Patients with severe mental illness, or severe anxiety and depression
- With comorbidities such as traumatic brain injury and cranial tumors
- A history of alcoholism, psychotropic substance abuse, etc.
- Patients with severe medical conditions and unstable vital signs that cannot tolerate the tests.
- Female in pregnancy
Key Trial Info
Start Date :
August 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2032
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT06101940
Start Date
August 1 2021
End Date
December 30 2032
Last Update
September 16 2025
Active Locations (22)
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1
Chinese People's Liberation Army General Hospital
Beijing, Beijing Municipality, China
2
Peking University First Hospital
Beijing, Beijing Municipality, China
3
First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
4
Fujian Medical University Union Hospital
Fuzhou, Fujian, China