Status:
RECRUITING
Genetic Susceptibility to Severe Infections
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Infectious Disease
Eligibility:
All Genders
Brief Summary
Only a fraction of individuals infected with microbes develop clinical disease. This observation raises fundamental questions about the pathogenesis of infectious diseases. There is a complex interact...
Detailed Description
Justification of the number of subjects: The prevalence of the various severe infections we wish to explore ranges from one case in 50,000 to one case in 1,000,000 individuals; consequently, we plan ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- to sign the informed consent signed by the patient. In the case of a minor patient, consent is signed by the holders of parental authority. In the case of a protected adult patient, the consent is signed by their legal representative. In the case of an adult patient unable to consent at the time of inclusion, consent is signed by a family member.
- to have a proven rare and severe infection
- to be hospitalized or followed in a specialized hospital department, in the emergency room or in intensive care
- to be affiliated to the French Social Security system
- for relatives, to be related to the index case up to the 3rd degree: Parents, Children, Brother, Sister, Grandparents, Uncles, Aunts, Cousins, Nephews, Nieces
- Exclusion Criteria
- to have an acquired immunodeficiency (having received immunosuppressive treatment in the 3 months preceding the onset of the disease or being HIV positive)
- pregnant woman at the time of illness
Exclusion
Key Trial Info
Start Date :
February 18 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 18 2038
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT06102070
Start Date
February 18 2022
End Date
October 18 2038
Last Update
March 19 2025
Active Locations (1)
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1
Centre d'Etudes des Déficits Immunitaires (CEDI), Hôpital Necker-Enfants
Paris, Île-de-France Region, France, 75015