Status:
RECRUITING
Oxygen Extraction-guided Transfusion
Lead Sponsor:
Università degli Studi di Ferrara
Conditions:
Blood Transfusion
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In critically ill patients, optimized strategies for red blood cells transfusion (RBCT) are still controversial. Most recent guidelines suggest that clinical practice in ICU setting should follow a re...
Eligibility Criteria
Inclusion
- Hb levels ≤ 9.0 g/dL (as confirmed through a blood test and/or through blood gas analysis)
- Presence of an arterial line and a central venous line (either jugular or subclavian), with confirmed correct position of the catheter tip at the atrio-caval junction (allowing correct estimation of central venous saturation, ScvO2).
Exclusion
- Age \< 18 years;
- Pregnancy
- Clinical evidence of acute bleeding
- Diagnosis of haematological malignancy
- Diagnosis of sickle cell disease, or other diseases exposing the patient to chronic RCBTs
- Acquired or congenital disorders of coagulation
- Patients with ongoing AKI of stage 1 or worse and/or known chronic kidney disease (CKD) of stage G3a or worse, defined as glomerular filtration rate below 60 for a minimum of 3 months
Key Trial Info
Start Date :
November 4 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
324 Patients enrolled
Trial Details
Trial ID
NCT06102590
Start Date
November 4 2023
End Date
January 1 2027
Last Update
July 31 2025
Active Locations (4)
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1
Hospital Erasme
Brussels, Belgium
2
Università di Ferrara
Ferrara, Ferrara, Italy, 44121
3
Università di Perugia
Perugia, Italy, Italy, 06121
4
Anestesia e Rianimazione Cardio-Toraco-Vascolare
Siena, Italy