Status:
RECRUITING
Quantitative Perfusion Imaging Using Contrast Enhanced Perfusion Ultrasound, MRI and Perfusion Angiography
Lead Sponsor:
University College, London
Conditions:
Vascular Diseases
Eligibility:
All Genders
40+ years
Brief Summary
Peripheral Arterial Disease is the narrowing and blocking of the blood vessels that supply the legs and feet. It is a common and progressive condition that affects patients of all backgrounds and gend...
Detailed Description
Participants in this study will either be a group of healthy disease-free participants or participants with peripheral arterial disease. In the Peripheral Arterial Disease group, participants care wi...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Disease-free participants:
- Adult patients older than 40 years old
- Subjects able to and willing to give informed consent
- Staff from University College London Hospital/University College London
- Participants with Peripheral Arterial Disease :
- Patients able to and willing to give informed consent
- Peripheral Arterial Disease Rutherford Classification stages 1- 6
- Patients referred by University College London Hospital or Royal Free Hospital.
- Exclusion Criteria
- Disease-free participants:
- Prior history of Peripheral Arterial Disease
- History of diabetes, tobacco smoking or cardiovascular, vasculitides or muscle disease
- Any contraindication to magnetic resonance imaging or contrast enhanced ultrasound- metal implants not compatible with magnetic resonance imaging; documented allergy to SonoVue; patients with right-to-left shunts assessed with transthoracic echocardiogram, severe pulmonary hypertension (pulmonary artery pressure \>90 mmHg), uncontrolled systemic hypertension, and in patients with adult respiratory distress syndrome and recent myocardial infarction/ acute coronary syndrome in the preceding 7 days.
- Participants not from University College London Hospital/University College London
- Peripheral Arterial Disease participants:
- Concurrent and/or recent involvement in other research that is likely to interfere with the intervention within 3 months of study enrolment
- Any contraindication to magnetic resonance imaging or contrast enhanced ultrasound - metal implants not compatible with magnetic resonance imaging; documented allergy to SonoVue; patients with right-to-left shunts assessed with transthoracic echocardiogram, severe pulmonary hypertension (pulmonary artery pressure \>90 mmHg), uncontrolled systemic hypertension, and in patients with adult respiratory distress syndrome and recent myocardial infarction/ acute coronary syndrome in the preceding 7 days.
- Patients outside University College London Hospital or Royal Free Hospital.
Exclusion
Key Trial Info
Start Date :
September 11 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 11 2025
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT06103708
Start Date
September 11 2023
End Date
September 11 2025
Last Update
April 24 2024
Active Locations (1)
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1
University College London Hospital
London, United Kingdom