Status:
UNKNOWN
Epigenetic Memory of Vitamin D Supplementation
Lead Sponsor:
Polish Academy of Sciences
Conditions:
Immune System Diseases
Infections
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The investigators will study the mechanistic details of dietary programming of the epigenome at the example of epigenetic programming of primary human immune cells with the micronutrient vitamin D3. T...
Detailed Description
Exposure to dietary molecules during adulthood creates an epigenetic memory in immune cells affecting disease risk in later years of life. Many nutritional molecules have a direct effect on the human ...
Eligibility Criteria
Inclusion
- Healthy adult (18-65 years)
Exclusion
- Smoker
- BMI \> 28 kg/m2
- History of kidney stones, renal failure or dialysis, hypercalcemia, hypo- or hyperparathyroidism, severe liver disease (cirrhosis), or sarcoidosis or other granulomatous diseases, such as active chronic tuberculosis or Wegener's granulomatosis
Key Trial Info
Start Date :
October 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 30 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06104111
Start Date
October 1 2023
End Date
March 30 2025
Last Update
October 27 2023
Active Locations (1)
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1
Institute of Animal Reproduction and Food Research
Olsztyn, Poland, 10-478