Status:
ACTIVE_NOT_RECRUITING
Indicator Amino Acid Oxidation in ICU Patients
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Critical Illness
Muscle Wasting
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study will use the indicator amino acid oxidation technique (IAAO) to determine protein oxidation of ICU patients at two protein intakes: 1.3 g/kg/d versus 2.0 g/kg/d.
Detailed Description
Rationale: While protein administration guidelines for critical care are available from international organizations such as ASPEN and ESPEN, they vary greatly in their recommended dose and are based ...
Eligibility Criteria
Inclusion
- ≥ 18 years old
- Unplanned admission to the ICU
- Mechanically ventilated
- Start of enteral nutrition within 2 days of intubation
- ≥ 3 days on enteral nutrition
- Expected remaining ICU stay on mechanical ventilation of ≥ 2 days
Exclusion
- Contra-indication for enteral nutrition at the discretion of the treating physician
- Feeding intolerance during incremental feeding protocol
- Moribund or withholding of treatment
- On extracorporeal membrane oxygenation (ECMO)
- Presence of chest drains, pneumothorax, tracheoesophageal fistula or subcutaneous emphysema
- Kidney failure AND a "no dialysis"-code on admission
- Hepatic encephalopathy (West Haven criteria 3-4)
- BMI \< 18 kg/m2
Key Trial Info
Start Date :
October 30 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT06104527
Start Date
October 30 2023
End Date
December 1 2025
Last Update
November 29 2024
Active Locations (1)
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1
Maastricht University Medical Center+
Maastricht, Limburg, Netherlands, 6229 HX