Status:
UNKNOWN
Autologous Micrografts From the Palatal Mucosa for Periodontal Regeneration
Lead Sponsor:
University of Turin, Italy
Conditions:
Periodontitis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Some research studies have demonstrated that autologous micrografts made out of different oral tissues may enhance tissue regeneration. The primary aim of this study is to evaluate the clinical perfor...
Eligibility Criteria
Inclusion
- Patients selected for the study should fulfil the following inclusion criteria:
- Affected from stage III-IV periodontitis.
- Completed non-surgical periodontal therapy.
- FMPS \<15% at 3-month re-evaluation.
- FMBS \<15% at 3-month re-evaluation.
- At least one site with an interproximal intrabony defects and residual PPD ≥ 6 mm at re-evaluation, with a radiographic intrabony component ≥ 3 mm, extending to the lingual/palatal side as assessed by preoperative bone sounding.
- Intrasurgically, the defect has to present a non-supporting anatomy (1-2 residual walls in its most coronal portion), requiring flap elevation on both buccal and oral side for its accessibility.
- Signed informed consent.
- Exclusion criteria:
- Compromised general health which contraindicates the study procedures (ASA III-VI patients).
- Systemic diseases/medications which could influence the outcome of the therapy (e.g. uncontrolled diabetes mellitus, non-plaque-induced gingival diseases, antiepileptic drugs (phenytoin and sodium valproate), certain calcium channel-blocking drugs (e.g., nifedipine, verapamil, diltiazem, amlodipine, felodipine), immunoregulatory drugs (e.g., cyclosporine), and high-dose oral contraceptives.
- Current smokers (self-reported), users of chewing tobacco, and drug/alcohol abusers.
- Pregnant or nursing women.
- Presence of furcation involvement ≥ II degree (Hamp 1975) at the affected teeth.
- Very large and wide defects that required the use of membrane.
Exclusion
Key Trial Info
Start Date :
November 2 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 2 2025
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT06105125
Start Date
November 2 2023
End Date
November 2 2025
Last Update
November 28 2023
Active Locations (1)
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1
CIR Dental School
Turin, Italy, 10126