Status:
ENROLLING_BY_INVITATION
Reducing Overuse of Antibiotics at Discharge Home
Lead Sponsor:
University of Utah
Collaborating Sponsors:
University of Michigan
Conditions:
Pneumonia
Urinary Tract Infection
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this two-arm parallel cluster-randomized trial of 40 hospitals is to test the effectiveness of the ROAD Home Intervention on days of antibiotic overuse at discharge in patients hospitalize...
Detailed Description
The Reducing Overuse of Antibiotics at Discharge (ROAD) Home study is designed to test the hypothesis that hospitals randomized to an implementation intervention that includes external facilitation to...
Eligibility Criteria
Inclusion
- All Patients:
- Adult patient admitted and discharged from the participating hospital and included in HMS registry
- Admitted to a general care medicine service
- Received any eligible antibiotic during the symptom collection window (-1 to +2 days for UTI; day 1 or 2 for pneumonia)
- Immunocompetent (allowing for mild immune suppression)
- Do not have a concomitant infection (e.g., antibiotic treatment for unrelated infection or prophylaxis)
- Specific inclusion criteria for patients with UTI:
- Positive urine culture
- Have normal urinary anatomy
- Specific inclusion criteria for patients with pneumonia:
- \- Discharge diagnosis of pneumonia
Exclusion
- All Patients:
- Left against medical advice or refused medical care
- Admitted on hospice
- Pregnant
- Unable to determine actual or expected antibiotic duration
- Specific exclusions for patients with UTI:
- \- spinal cord injury
- Specific exclusions for patients with pneumonia:
- Cystic fibrosis
- Pneumonia-related complication (e.g., empyema)
Key Trial Info
Start Date :
November 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2028
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06106204
Start Date
November 1 2023
End Date
August 31 2028
Last Update
January 1 2025
Active Locations (1)
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1
University of Utah
Salt Lake City, Utah, United States, 84132