Status:
RECRUITING
Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma
Lead Sponsor:
Columbia University
Collaborating Sponsors:
Varian Medical Systems
Conditions:
Glioblastoma
Anaplastic Astrocytoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to find out if performing additional Magnetic Resonance Image (MRI) scans of the subjects' brain during each week of the radiation treatment of their high-grade glioma wil...
Detailed Description
Diffusion weighted imaging (DWI) and Perfusion-weighted imaging (PWI) are validated MRI techniques that aid in diagnosis, prognosis, and assessment of treatment efficacy and, while they are utilized i...
Eligibility Criteria
Inclusion
- Histopathologically proven diagnosis of glioblastoma, anaplastic astrocytoma, or anaplastic oligodendroglioma
- History and physical examination within 28 days prior to enrollment
- Karnofsky performance status 70 or greater
- Age 18 years or greater
- Negative pregnancy test for females of childbearing potential before 1st research MRI, performed in accordance to institutional guidelines.
- Plan to receive 59.4-60 Gy in 30-33 fractions of radiotherapy. Glioblastoma patients over 65 year-old can receive hypofractionated radiotherapy including 40 Gy in 15 fractions.
Exclusion
- Prior therapy for tumor except for biopsy or resection, including prior radiotherapy to the brain.
- Clinical or radiological evidence of metastatic disease outside the brain
- Prior malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 2 years
Key Trial Info
Start Date :
January 30 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT06108206
Start Date
January 30 2024
End Date
December 1 2027
Last Update
July 3 2025
Active Locations (1)
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1
Columbia University Irving Medical Center/NYPH
New York, New York, United States, 10032