Status:
COMPLETED
Activin-A and Interleukin-1β Levels in Periodontitis
Lead Sponsor:
Aydin Adnan Menderes University
Conditions:
Periodontitis
Gingivitis
Eligibility:
All Genders
27-48 years
Brief Summary
Activin-A belongs to the transforming growth factor-beta superfamily and is a multifunctional cytokine that plays a role in inflammation, immune response, tissue repair and regeneration. Proinflammato...
Detailed Description
Participants were divided into three groups according to the diagnostic criteria proposed by the Classification of Periodontal and Peri-implant Diseases and Conditions; I. Periodontitis group (n=23), ...
Eligibility Criteria
Inclusion
- the presence of no history of smoking (determined by self-reporting)
- at least 18 natural teeth excluding 3rd molars.
Exclusion
- the presence of systemic conditions (diabetes mellitus, rheumatoid arthritis, cardiovascular system diseases, endocrine, immunologic, and mucocutaneous disorders) - use of antibiotics, antihypertensives immunosuppressive and anti-inflammatory drugs within the past 6 months and topical antiseptic solutions in the last 3 months
- having periodontal treatment in the previous year
- wearing removable partial dentures or orthodontic appliances
- restorative and endodontic therapy requirements
- pregnant or nursing women.
Key Trial Info
Start Date :
March 22 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 2 2020
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT06110221
Start Date
March 22 2019
End Date
February 2 2020
Last Update
October 31 2023
Active Locations (1)
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1
Aydın Adnan Menderes University
Aydin, Turkey (Türkiye), 09100