Status:
UNKNOWN
Initial Resuscitation With Albumin in Hemorrhagic Shock to Reduce Positive Fluid Balance
Lead Sponsor:
Seoul National University Hospital
Conditions:
Bleeding
Massive Hemorrhage
Eligibility:
All Genders
19+ years
Phase:
NA
Brief Summary
This study is designed to evaluate the effect of early albumin transfusion within massive transfusion protocol on fluid balance and reduced requirement of transfusion.
Detailed Description
Eligible patients who require massive transfusion will be randomized in a single-blind manner (participant) in a 1:1 ratio to Conventional Massive Transfusion Pro. tocol group (C-MTP) or Albumin Massi...
Eligibility Criteria
Inclusion
- Adult patients (19 or older)
- Admitted or planned to admit surgical intensive care unit
- Patients with decreased hemoglobin level more than 20% from baseline within 12 hours, Or
- Patients who are suspected bleeding and hemodynamically unstable requiring more than 0.05mcg/kg/min of norepinephrine infusion to maintain mean blood pressure higher than 65mmHg
Exclusion
- Contraindicated to albumin product
- patients with risk factors of increased circulatory volume (heart failure, pulmonary edema, end-stage renal disease with oliguria)
- patients with hemolytic anemia
- History of anaphylactic reaction to blood product
Key Trial Info
Start Date :
November 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 15 2025
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT06111261
Start Date
November 15 2023
End Date
August 15 2025
Last Update
November 1 2023
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