Status:
ACTIVE_NOT_RECRUITING
Effect of Dapagliflozin on the Recurrence of Atrial Tachyarrhythmia in Patients Undergoing Catheter Ablation of Atrial Fibrillation
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Atrial Fibrillation Recurrent
Catheter Ablation
Eligibility:
All Genders
20+ years
Phase:
PHASE2
PHASE3
Brief Summary
The goal of this clinical trial is to test the effect of Dapagliflozin on the Recurrence of Atrial Tachyarrhythmia in Patients Undergoing Catheter Ablation of Atrial Fibrillation. The main questions i...
Detailed Description
This trial is the third phase of random allocation and non-blind trial. It is divided into study group and control group. The study group is Dapagliflozin therapy, and the treatment period is three mo...
Eligibility Criteria
Inclusion
- Ability to give written informed consent
- Men and women age \>= 20 years.
- Paroxysmal, persistent or long-standing persistent atrial fibrillation
- eGFR \>= 25 ml/min/1.73 m2
Exclusion
- Receiving therapy with a sodium-glucose cotransporter 2 (SGLT2) inhibitor prior to randomization, or intolerance to an SGLT2 inhibitor.
- Type 1 diabetes mellitus
- Acute coronary syndrome, coronary revascularization (percutaneous coronary intervention or Coronary artery bypass grafting), ablation of atrial flutter/fibrillation, ischemic stroke, and transient ischemic attack within 12 weeks prior to randomization
- Active malignancy
- Women of child-bearing potential who have a positive pregnancy test at randomization or who are breast-feeding
- A life expectancy of fewer than 2 years due to any non-cardiovascular condition, based on the investigator's clinical judgment
- Expected surgery for structural heart disease, and secondary atrial fibrillation (due to cardiac surgery, infection, or hyperthyroidism)
Key Trial Info
Start Date :
December 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2026
Estimated Enrollment :
196 Patients enrolled
Trial Details
Trial ID
NCT06111443
Start Date
December 1 2023
End Date
November 30 2026
Last Update
December 21 2023
Active Locations (1)
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1
Kaoshiung Chang Gung Memorial
Kaohsiung City, Taiwan