Status:
RECRUITING
Quantitative Computed Tomography for Mortality Risk Stratification in ARDS
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Acute Respiratory Distress Syndrome
Eligibility:
All Genders
15+ years
Brief Summary
Acute respiratory distress syndrome remains a deadly disease with hospital mortality remaining between 40 to 50%. ARDS mortality risk factors have been identified from patient history, common clinical...
Eligibility Criteria
Inclusion
- Patient aged 15 or older with ARDS according to the Berlin definition
- invasive mechanical ventilation with PaO2/FiO2 ≤ 300 mm Hg
- with computed tomography acquired at both end-expiration and end-inspiration, or at both PEEP 5 and 15 cm H2O at end-expiration
- PEEP setting according to a PEEP/FiO2 table, with secondary adjustment according to hemodynamic tolerance
- Tidal volume 6 ml/kg of predicted body weight or less
Exclusion
- Use of contrast agent during computed tomography acquisition
- ARDS criteria onset since more than 72 hours or ECMO onset since more than 72 hours
- Proven COPD
- Pneumothorax or bronchopleural fistula
- Patient with spontaneous breathing preventing realization of end-expiratory and end-inspiratory pauses
- Previous inclusion in current study
- Patient under a legal protective measure
Key Trial Info
Start Date :
November 6 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2025
Estimated Enrollment :
210 Patients enrolled
Trial Details
Trial ID
NCT06113276
Start Date
November 6 2020
End Date
May 1 2025
Last Update
January 31 2024
Active Locations (4)
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1
Service de Médecine Intensive Réanimation Hôpital Michallon - CHU Grenoble Alpes
La Tronche, France, 38700
2
Hospices Civils de Lyon - Hôpital de la Croix Rousse - Service de Médecine Intensive Réanimation
Lyon, France, 69004
3
Service de Réanimation Polyvalente Centre Hospitalier Lyon Sud Hospices Civils de Lyon
Pierre-Bénite, France, 69310
4
Centre Hospitalier Universitaire de Rennes
Rennes, France