Status:
NOT_YET_RECRUITING
Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity (GENOBE)
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Monogenic Obesity
Non Syndromic Obesity
Eligibility:
All Genders
2-6 years
Brief Summary
Non-syndromic monogenic obesity is a group of rare diseases characterized by severe and early onset obesity. Genetic characterization of these rare forms is important to target patients who may benefi...
Detailed Description
Obesity is a frequent disease mainly caused by environmental/polygenic factors and more rarely caused by the alteration of a single gene ("monogenic obesity"). The diagnosis of these rare forms can le...
Eligibility Criteria
Inclusion
- o For Patient cohort :
- Inclusion criteria:
- Body mass index above the International Obesity Task Force 30 curve by age 6.
- Consent for genetic testing signed with agreement to use secondary data for research purposes.
- Exclusion criteria : Opposition of the patient to the research - This opposition of the patient must be received by the investigator of the center within a maximum of 1 month after the sending of the information note.
- o For Control cohort :
- Inclusion criteria:
- Body mass index under 25 kg/m2 after age 18 and no history of obesity.
- Signed consent for genetic testing with agreement to use biological samples and secondary data for research purposes.
- Exclusion criteria:
- Opposition of the patient to the research - This opposition of the patient must be received by the investigator of the center within a maximum of 1 month after the sending of the information note.
- Degraded DNA
Exclusion
Key Trial Info
Start Date :
February 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06113523
Start Date
February 1 2024
End Date
February 1 2026
Last Update
November 2 2023
Active Locations (1)
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1
Centre Hospitalier Universitaire de Bordeaux
Bordeaux, France, 33400