Status:
UNKNOWN
Study Comparing Chronic Beryllium Disease to Pulmonary Sarcoidosis
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Pulmonary Sarcoidosis
Chronic Beryllium Disease
Eligibility:
All Genders
18+ years
Brief Summary
Inhalation of beryllium can induce specific sensitization and diffuse pulmonary granulomatosis called chronic beryllium disease (CBD). The clinical, radiographic, and anatomopathological features of C...
Detailed Description
Inhalation of beryllium can induce specific sensitization and diffuse pulmonary granulomatosis called chronic beryllium disease (CBD). The clinical, radiographic, and anatomopathological features of C...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Sufficiently documented medical record.
- Informed patients who did not object to participating in the research, or for deceased patients, did not object to the use of their data.
- Cases: Patients followed for confirmed chronic beryllium disease by expert teams based on the ATS 2014 criteria, i.e., a history of exposure to beryllium, positivity of two abnormal lymphocyte proliferation tests (LPT) in blood and/or an abnormal LPT in bronchoalveolar lavage, granuloma found in pulmonary biopsy associated by compatible clinical, radiological or spirometric abnormalities.
- Controls: Patients followed for sarcoidosis according to the ATS/ERS/WASOG criteria, i.e., (i) a compatible presentation, (ii) the presence of non-necrotizing granulomatosis in one or more tissues (except Löfgren's syndrome or Heerfordt syndrome), (iii) and exclusion of alternative causes of granulomatous diseases with pulmonary parenchymal involvement on thoracic CT and/or chest radiography.
- Controls: without occupational exposure to beryllium.
Exclusion
- Patients under trustee.
Key Trial Info
Start Date :
June 14 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 14 2023
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06113991
Start Date
June 14 2023
End Date
December 14 2023
Last Update
November 2 2023
Active Locations (1)
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1
001 - Service Pneumologie
Bobigny, Avicenne, France