Status:
RECRUITING
StrokeCog-BBB to Study Cognitive Outcomes Following Stroke
Lead Sponsor:
Stanford University
Collaborating Sponsors:
University of Manchester
Columbia University
Conditions:
Stroke
Eligibility:
All Genders
45-90 years
Brief Summary
The goal of this observational study is to learn about cognitive outcomes in stroke patients. The main question it aims to answer are: 1. Is blood-brain barrier permeability compromised for years afte...
Detailed Description
Post-stroke dementia is an important and understudied component of the vascular contributions to cognitive impairment and dementia. Having a stroke approximately doubles the risk of incident dementia ...
Eligibility Criteria
Inclusion
- Aged 45 years or over
- One or more vascular risk factors (e.g. high blood pressure, diabetes or vascular disease such as angina, a previous heart attack, a heart bypass or peripheral artery disease in the legs)
- Established vascular disease (previous MI, angina, vascular stent in the peripheral bed)
- Sufficiently fluent in written and spoken English
- Living independently in the community
- Willing/able to give consent to study participation.
Exclusion
- Current treatment with IL-1 blockade or established immune-suppressant therapy (e.g. IL-1Ra or IL-1 antibodies), or treatment within the last 3 months
- Currently participating in a clinical trial of investigation medicinal product (CTIMP) or device trial.
- No history of any previous ischaemic or haemorrhagic stroke, a mini-stroke or a serious brain injury
- Do not have dementia
- Renovascular Disease
- Major neurological disease (immune mediated, previous brain tumors)
Key Trial Info
Start Date :
May 17 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
350 Patients enrolled
Trial Details
Trial ID
NCT06116630
Start Date
May 17 2022
End Date
December 31 2027
Last Update
April 18 2024
Active Locations (1)
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1
Stanford University Hospital
Palo Alto, California, United States, 94304