Status:
RECRUITING
Changes in Host Gene Expression to Differentiate Between Systemic Inflammation and Infection After Major Surgery
Lead Sponsor:
St. Antonius Hospital
Collaborating Sponsors:
Amphia Hospital
Conditions:
Infections
Sepsis
Eligibility:
All Genders
18+ years
Brief Summary
Changes in host gene expression may provide additional information to diagnose postoperative infection and improve outcome after surgery. This study aims to validate the early diagnostic performance o...
Detailed Description
Rationale: Differentiation between the systemic inflammatory response syndrome (SIRS) and infection after surgery is challenging. Consequent diagnostic uncertainty may result in delayed diagnosis and ...
Eligibility Criteria
Inclusion
- Age \>18 years
- Major noncardiac surgery with infection risk \>20%
Exclusion
- Age \<18 years
- Emergency surgery
- Inability to provide informed consent.
Key Trial Info
Start Date :
December 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT06116656
Start Date
December 1 2024
End Date
June 1 2026
Last Update
December 16 2024
Active Locations (2)
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1
Amphia hospital
Breda, Netherlands
2
St Antonius hospital
Nieuwegein, Netherlands