Status:
RECRUITING
Evaluation of APOL1 Gene Variants in Kidney Donors and Their Impact on Long-term Renal Function in Donors and Recipients
Lead Sponsor:
Hospital do Rim e Hipertensão
Conditions:
Kidney Diseases
Transplant Failure
Eligibility:
All Genders
Brief Summary
Evaluation of the frequency of APOL1 gene variants in kidney donors and the impact of these variants on the long-term renal function of kidney transplant donors and recipients.
Detailed Description
Introduction: Chronic kidney disease (CKD) is a worldwide public health problem and kidney transplantation, when indicated, is the treatment of choice for CKD. Kidney transplant survival at the end of...
Eligibility Criteria
Inclusion
- 1.1.1. Inclusion criteria 1.1.1.2. For recipients:
- Living donor kidney transplant recipients, performed at Hospital do Rim from January 1, 2008 to March 31, 2015;
- Recipients Who have reached one year after the transplant, with a functioning renal graft;
- Recipients whose donors were located agreed to participate in the research, signed the informed consent form (TCLE) and submitted to the collection of exams.
- For donors:
- Living kidney donors whose donation was made at the Hospital do Rim in the period between January 2008 and December 2015;
- That they are alive at the time the study begins;
- Who have signed the TCLE.
Exclusion
- For recipients:
- Recipients who have undergone the transplant under the age of 18 years;
- Recipients who have previously undergone transplantation of other organs; 1.1.3.3. For donors: Donors Who withdraw the informed consent form at any stage of the study.
Key Trial Info
Start Date :
October 15 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 30 2025
Estimated Enrollment :
2450 Patients enrolled
Trial Details
Trial ID
NCT06116721
Start Date
October 15 2023
End Date
November 30 2025
Last Update
February 28 2024
Active Locations (1)
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1
Hospital do Rim
São Paulo, São Paulo, Brazil, 04038-002