Status:
UNKNOWN
Efgartigimod in Acute Neuromyelitis Optica Spectrum Disorders
Lead Sponsor:
Feng Jinzhou
Conditions:
Neuromyelitis Optica
Efgartigimod
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to retrospective investigate the safety and effectiveness of Efgartigimod in the acute phase of neuromyelitis optica spectrum disorders (NMOSD) patients.
Detailed Description
This is a multicentre, controlled, retrospective, real-world study which aims to compare the safety and effectiveness of Intravenous methylprednisolone (IVMP) with Efgartigimod injection add-on treatm...
Eligibility Criteria
Inclusion
- 1\. Age ≥ 18 years with anti-AQP4-IgG seropositive NMOSD as defined by 2015 NMOSD diagnostic criteria by IPND (International Panel for NMO Diagnosis).
- 2\. Patients in the acute phase of NMOSD (definition of acute phase: new neurological symptoms or aggravation of existing symptoms within 30 days before received treatment, lasting at least 24 hours without fever), who had poor response to IVMP and without having received second-line therapies such as plasma exchange or intravenous immunoglobulin consequencely (Poor response is defined as a reduction in EDSS score of: I. \<1.0 from the baseline EDSS score when the baseline score was \<=5.5 II. \< 0.5 when the baseline EDSS score \> 5.5).
- 3\. Patients who were approved for Efgartigimod treatment would be enrolled in the exposed group.
- 4\. Expanded disability status scale (EDSS) score ≤ 8 and ≥ 2.5 before treatment.
- 5\. Patients have given their written informed consent.
Exclusion
- 1\. Lactating and pregnant females before treatment.
- 2\. Participated in other interventional studies within 30 days before treatment.
- 3\. Received plasma exchange, immunoadsorption, or intravenous immunoglobulin (IVIG） therapy within 1 month before treatment.
- 4\. History of malignancies.
- 5\. Combined with severe mental disorders and other conditions that unable to cooperate with follow-up.
- 6\. After being evaluated by experts, patients with active hepatitis, active tuberculosis, or other special conditions which were ineligible to participate in this study.
Key Trial Info
Start Date :
November 5 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 5 2025
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT06118398
Start Date
November 5 2023
End Date
May 5 2025
Last Update
November 7 2023
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