Status:
RECRUITING
Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrtho)
Lead Sponsor:
Istituto Ortopedico Rizzoli
Conditions:
Spinal Fusion
Eligibility:
All Genders
12-75 years
Brief Summary
The goal of this observational study is to learn about endothelial damage in major spine surgery, expressed as rise in circulating Syndecan-1. The main questions it aims to answer are: * What is the...
Detailed Description
The aim of this study is to gain information about endothelial damage in major spine surgery, expressed as shedding of glycocalyx component Syndecan-1, and subsequent rise of its plasma levels. This ...
Eligibility Criteria
Inclusion
- Undergoing Major Spine Surgery with estimated blood loss\> 25% of total blood volume
- American Society of Anesthesiology status 1-2-3
- Able to comprehend and sign informed consent.
- If age \<18 years: parent or legal representative able to comprehend and sign informed consent
Exclusion
- Surgery outside of laboratory opening hours
- Patients undergoing spine surgery for genetic syndromes/neuromuscular scoliosis
Key Trial Info
Start Date :
February 28 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 28 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT06119542
Start Date
February 28 2022
End Date
February 28 2026
Last Update
November 13 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Sandra Giannone
Bologna, BO, Italy, 40128