Status:
UNKNOWN
Dynamic Chest X-ray With Simultaneous Spirometry
Lead Sponsor:
Liverpool Heart and Chest Hospital NHS Foundation Trust
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
17-50 years
Brief Summary
Dynamic chest X-ray (DCR) is a novel radiographic technique that enables us to visualise the movement of the chest and lungs in real-time by recording a series of x-ray images over 10-20 second interv...
Detailed Description
Dynamic chest X-ray (DCR) records images of the chest in motion in a 'recording' over 10-20 seconds. This is essentially a video x-ray of the chest and associated structures involved in breathing. The...
Eligibility Criteria
Inclusion
- Part A: Real-time paired DCR and Spirometry in Healthy cohort with no underlying respiratory diagnosis
- Inclusion criteria:
- Age: ≥ 17 years old and \<\_ 50 years old
- No underlying respiratory illness (chronic or acute). Individuals with an Asthma diagnosis requiring short-acting bronchodilators only will be eligible
- Able to provide informed consent
- Exclusion criteria:
- General exclusion criteria:
- Any of:
- Potentially pregnant or lactating
- Inability to provide informed consent
- Unable or unwilling to sit to perform Dynamic chest x-ray/Spirometry in the radiology department
- Unable or unwilling to follow Spirometry breathing instructions (e.g., holding breath or taking a deep breath)
- Unable to perform reproducible spirometry and/or full pulmonary function studies within American Thoracic Society and European Society joint criteria
- Significant radiation exposure within the last year (for example, numerous CT scans of chest)
- Involved, either currently or recently, in other studies involved non-routine exposure to sources of ionising radiation
- Any serious or active medical or psychiatric illness, which in the opinion of the investigators, would interfere with subject treatment, assessment, or compliance with the protocol
- Inability to complete spirometry in 20 seconds.
- Current Chest infection
- Spirometry exclusion criteria
- Any of:
- Unstable cardiovascular status, recent myocardial infarction or pulmonary embolism (within 6 weeks)
- Haemoptysis of unknown aetiology (within 6 weeks)
- Pneumothorax (present, or occurring within 6 weeks)
- Within 24 hours of bronchoscopy
- Thoracic, abdominal or cerebral aneurysm
- Recent eye surgery or increased intraocular pressure
- Recent thoracic or abdominal surgery
- Acute nausea, vomiting or diarrhoea
- Pregnancy
- Undergoing treatment for tuberculosis
- Part B: Real-time paired DCR and spirometry in a CF subgroup
- Inclusion criteria:
- Age: ≥ 17 years old and
- Attending the adult CF Unit at Liverpool heart and Chest Hospital and
- Confirmed CF diagnosis (positive sweat test in childhood and by genotyping) and
- Able to provide informed consent
- General exclusion criteria, same as Group A (see above) plus:
- Recipient of Lung transplant
- Current exacerbation Spirometry exclusion criteria (same as for Group A, see above)
Exclusion
Key Trial Info
Start Date :
November 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2025
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT06122051
Start Date
November 1 2023
End Date
August 1 2025
Last Update
November 8 2023
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