Status:
COMPLETED
The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capillary Refill Time In Adult Patients With Septic Shock
Lead Sponsor:
Kasr El Aini Hospital
Collaborating Sponsors:
Mansoura University
Conditions:
Septic Shock
Resuscitation
Eligibility:
All Genders
19-60 years
Phase:
PHASE3
Brief Summary
The aim of this study is to compare the effect of resuscitation guided by Left ventricular outflow tract-velocity time integral (LVOT-VTI) variation versus the effect of resuscitation guided by inferi...
Detailed Description
Capillary refill time will be measured by applying firm pressure to the ventral surface of the right index finger distal phalanx with a glass microscope slide. The pressure will be increased until the...
Eligibility Criteria
Inclusion
- adult patients ( ≥ 18 years) of either gender with septic shock according to the Sepsis-3
Exclusion
- Known history of any cardiac pathology, acute coronary syndrome, cardiac dysrhythmias (as a primary diagnosis), acute pulmonary edema or known poor systolic cardiac function (left ventricular ejection fraction \< 50%).
- Body mass index ≥ 35 kg/m2 .
- Concomitant acute respiratory distress syndrome) or high PEEP (\> 10 cmH2O) requirements on mechanical ventilation (MV).
- Child B or C liver cirrhosis.
- End-stage renal disease with or without dialysis.
- Pregnancy.
- Multi-organ system failure.
- Active hemorrhage.
- Head trauma.
- Intra-abdominal hypertension (\> 15 mmHg).
- Declined to consent.
Key Trial Info
Start Date :
July 21 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2025
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT06122909
Start Date
July 21 2023
End Date
January 1 2025
Last Update
April 29 2025
Active Locations (2)
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1
Mansoura University, Central Hospital
Al Mansurah, Dakahlia Governorate, Egypt, 35511
2
Cairo university hospitals, kasralainy
Cairo, Egypt, 11559