Status:
COMPLETED
Efficacy and Safety of Sertraline in the Treatment of Maintenance Hemodialysis Patients With Depression
Lead Sponsor:
First Affiliated Hospital of Chongqing Medical University
Conditions:
Efficacy, Team
Adverse Reaction to Drug
Eligibility:
All Genders
18-90 years
Phase:
PHASE4
Brief Summary
Depression is a common mental disorder in patients undergoing maintenance hemodialysis (MHD), which increases the risk of cardiovascular events, hospitalization rates, and mortality, but has not recei...
Detailed Description
The HAMD, the Medication Adherence Report Scale-5 (MARS-5), the Mini Nutritional Assessment short-form (MNA-SF) and the Kidney Disease Quality of Life-36 (KDQOL-36) scales were used to evaluate change...
Eligibility Criteria
Inclusion
- Long-term MHD patients in the blood purification center of our hospital, older than 18 years old, maintenance dialysis for at least 3 months, 2-3 times a week, 3-4.5 hours each time;
- Meet the CKD5 diagnostic criteria;
- The cardiopulmonary function was relatively stable before enrollment, and the life expectancy was more than 1 year;
- The clinical data were basically complete;
- Consciousness, intelligence is normal, can understand the questionnaire content.
Exclusion
- Communication, communication disorders or other psychiatric history;
- Combined with active pulmonary tuberculosis, AIDS, severe infection patients;
- Pregnant or lactating women;
- Those who are taking antidepressants or other antipsychotic drugs;
- Unable or unwilling to cooperate with the researcher.
Key Trial Info
Start Date :
January 10 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 29 2023
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT06124417
Start Date
January 10 2022
End Date
September 29 2023
Last Update
November 9 2023
Active Locations (1)
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1
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400016